Streptozotocin으로 유도된 당뇨 백서와 비당뇨 백서에서 발치와의 치유과정에 관한 실험적 비교연구
An Experimental Study on the Healing of Extraction Socket Streptozotocin-Induced Diabetic Rats
단국대치의학연구소논문집 1993년 5권 1호 p.103 ~ 112
손창원, 김경욱, 임창준,
소속 상세정보
손창원 ( ) - 단국대 치의학연구소
김경욱 ( ) - 단국대 치의학연구소
임창준 ( ) - 단국대 치의학연구소
KMID : 0354619930050010103
Abstract
The healing effect of D.M. on fracture, wound, extraction socket, oral soft tissue have been studied. In recent studies, Glickman researched about the new bone formation in periodontal disease under D.M. streptozotocin, used as D.M. inducer in
experimental animals, has been used as broad spectrum antibiotics, anticancer drugs and carcinogen since 1960 years. Interestingly nowadays streptozotocin in use to make the experimental diabetic animal model.
Following microscopic examination of healing of extraction sockets in non-diabetic rats and that of streptozotocin induced diabetic rats.
@ES The results were as follows :
@EN 1. Trabecular formation consisting of osteoid could be seen in extraction sockets in control group(non-diabetic rats( after 1 week.
2. More chronic inflammation and less granulation tissue were seen in experimental group than control group after 1 week.
3. Trabecular pattern was seen after 4 weeks in experimental group. Trabecular pattern in control group was seen from 2 weeks specimen and became hardened after 4 weeks.
4. Experimental group showed delayed revascularization, poor granulation tissue formation and incomplete trabecular formation. So it is suggested that D.M. has much more adverse effect on the healing process of the extraction sockets.
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